It was first described more than 60 years ago but only recently started to be more noted and looked into.
In 2011 the 𝘌𝘶𝘳𝘰𝘱𝘦𝘢𝘯 𝘍𝘰𝘰𝘥 𝘚𝘢𝘧𝘦𝘵𝘺 𝘈𝘨𝘦𝘯𝘤𝘺 raised concerns regarding the high levels of amines (histamine included) present in foods bought in supermarkets, which might be considered a health risk.
Symptoms can happen due to either deficiency of the enzymes that degrade histamine or medication, leading to decreased enzymatic activity.
The main symptoms depend on the organs affected
The best way to reduce symptoms is by either reducing or stopping eating foods containing histamine or taking antihistamines.
The use of DAO (Diamine Oxidase) supplements is still debatable.